By Yoichi Shimada, Naohisa Miyakoshi
From a reassessment of osteoporosis to contributing elements, medical purposes of antiosteoporotic brokers, and rehabilitation, this booklet examines quite a few facets of the illness and its remedy. Edited and written from an orthopedic viewpoint, it techniques osteoporosis as either a metabolic affliction and a locomotive syndrome. As orthopedic surgeons in Japan are chargeable for pharmacotherapy, surgical procedure, and ache keep an eye on, the authors pursue a complete process, focusing in particular at the influence on muscular tissues and on fracture operation instead of increasing the scope to bone density.
Osteoporosis in Orthopedics offers broad content material and insights for clinicians, researchers, scientific scholars, and post-docs focusing on osteoporosis. It additionally deals a invaluable source for orthopedic and backbone surgeons who desire broad wisdom of osteoporosis and bone metabolism within the context of sufferer care.
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Additional info for Osteoporosis in Orthopedics: Assessment and Therapeutic Options
8 M. Saito and K. Marumo Other Factors for Poor Bone Quality: Diabetes and Chronic Kidney Disease In meta-analysis, Vestergaard showed that fractures occur in patients with type 2 diabetes and high BMD, and deterioration of bone quality began to be considered as the cause of fractures . The authors of the present article examined spontaneously diabetic WBN/Kob rats. The results showed that when persistent hyperglycemia and vitamin B6 deficiency due to impaired insulin action develop, enzymatic cross-linking decreases and AGE cross-linking increases in bone collagen, resulting in decreased bone strength without a decrease in BMD  (Fig.
Low BMD + low bone quality osteoporosis” is a condition in which both BMD and homocysteine metabolism decrease. 2-fold in patients with low BMD + low bone quality osteoporosis. YAM young adult mean BMD (Modified from Shiraki et al. ) low BMD + low bone quality type, respectively, showing that the low bone quality type was not rare. 10 Potential of Therapeutic Drug Use Based on BMD and Bone Quality Markers In a recent study, the authors of the present article have shown that drugs for osteoporosis can be used based on osteoporosis type classified by BMD and bone quality .
Once the building begins to collapse, it can completely collapse easily  collapse, but the frequency of severe vertebral collapse markedly increased when there was a high level of urinary pentosidine, a bone quality marker. Thus, one must be mindful that when patients have both low BMD and high urinary pentosidine levels, the risk for incident fracture increases and simultaneously the risk for severe vertebral collapse increases. Such patients with severe collapse are in a high risk group for incident fracture (vertebral or proximal femoral fracture).