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By G. Klein (auth.), Dr. Michael Potter, Professor Dr. Fritz Melchers, Dr. Martin Weigert (eds.)

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Extra resources for Oncogenes in B-Cell Neoplasia: Workshop at the National Cancer Institute, National Institute of Health, Bethesda, MD, USA, March 5–7, 1984

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Gene 18:175-185 Vogt, M & Dulbecco, R (1963) Steps in the neoplastic transformation of hamster embryo cells by polyoma virus. Proc Natl Acad Sci USA 49:171-179. Genome Structure and Host Range Restriction of the Lymphotropic Papovavirus (LPV): Identification of a Viral Lymphocyte Specific Enhancer Element M. Pawlita, L. Mosthaf*, A. Clad** and P. Gruss* Deutsches Krebsforschungszentrum, 1m Neuenheimer Feld 280, D-6900 Heidelberg, FRG *Institut fUr Mikrobiologie and Zentrum fUr Molekulare Biologie, Univers.

Of Pathology Harvard Medical School, Boston, MA 02115 INTRODUCTION The transforming activity of tumor DNAs, detected by transfection of NIH 3T3 cells, has resulted in the identification of a variety of transforming genes which are activated in human neoplasms. Activated oncogenes of the ras family have been detected in approximately 20% of human neoplasms, includingl:arcinomas, sarcomas, neuroblastomas, leukemia, and lymphomas (reviewed in Cooper and Lane, 1984). Thus, ras genes can apparently contribute to the development of neoplasms originating from-a wide variety of differentiated cell types.

Campisi, J, Gray, HE, Pardee, AB, Dean, M, and Sonenshein, G (1984) Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation. Cell 36: 241-247. Feldman, LT, early early Proc. Imperiale, MJ, and Nevins, JR (1982) Activation of adenovirus transcription by the herpesvirus immediate gene: evidence for a common cellular control factor. Nat'1. Acad. Sci. USA 79: 4952-4956. Graham, FL, Smiley, J, Russell, WC, and Nairn, R (1977) Characteristics of a human cell line transformed by DNA from human adenovirus 5.

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