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By Prasad S. Sunkara

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1982) and spleen (Olsson and Kaplan, 1980). , 1983; Olsson and Kaplan, 1983). , 1982; Kozbor and Roder, 1983) have been successful. Two methods for human lymphocyte immortalization are available: fusion to human myeloma cells in culture, and EBV-induced transfor­ mation. /. Advantages of Human MAb Compared to Mouse MAb There are two main advantages in using human MAb for the diagnosis and treatment of cancer. Human antibodies are clearly preferable for serotherapy to prevent sensitization with xenoantisera.

Human antibodies are clearly preferable for serotherapy to prevent sensitization with xenoantisera. , 1982c) that has apparently contributed to less marked uptake 2. , 1982a,b). Human antibodies are therefore also preferable for radioimmunodetection of tumor if repeated scans are antici­ pated. It may also be expected that the human response to polymorphic surface determinants may be to a wider range of antigens than the immunodominant determinants recognized by the mouse. Tumor-specific or tumor-associated anti­ gens may be much easier to identify using human M Ab.

This capability may be important, because studies on oncogenes and oncogene products as markers and causes of cancer (reviewed by Bishop, 1982) have demonstrated that the oncogene product in a human bladder carcinoma cell line differs from the normal cellular counterpart by a single amino acid (Tabin et al, 1982; Taparowsky et al, 1982). b. Immunization in Vitro. Immunization of cells in vitro, by incubation of dissociated spleen cells with antigen in culture, in the presence of growth factors produced by thymocytes (reviewed by Reading, 1982), was first reported by Hengartner et al.

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