By P Boisseau; P Houdy; M Lahmani; European Materials Research Society
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Additional resources for Nanoscience : nanobiotechnology and nanobiology
Note that a negative superhelicity favours transcriptional activity. Indeed, the RNA polymerase binds very well on circular DNA with a negative superhelicity but only weakly on relaxed circular DNA. This is one reason why transcription occurs near nucleosomes. One of the last points to consider is the fact that stresses induced on the helix by a positive or negative superhelicity can generate major structural changes in the helix as a secondary eﬀect. This is the case with regard to the formation of cruciform structures when there are palindromic sequences (see Fig.
Brisson Molecular and supramolecular understanding of the architecture of biological systems, and in particular membranes, can provide an extraordinary source of inspiration for making ‘intelligent’ nanostructures, based on the self-assembly properties of biological molecules. Bioelectronic interfacing between living and inert matter constitutes one of the most promising areas of development in nanobiotechnology. The present chapter is particularly concerned with the description of biological membranes and the self-association properties of the molecules making them up.
Acad. Sci. USA 80, 6206 (1983) 10. : Eﬀect of intercalative binding compared to external binding on Z/B equilibrium of poly-d(Gme5C) using ﬂuorescent oxazolopyridocarbazoles as probes, J. Mol. Recognit. 2 (4), 152–157 (1989) 11. : Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases, Nature 437, 1183 (2005) 12. : Crystal structure of the Za domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA, Science 284, 1841–1845 (1999) 13. 55 ˚ A crystal structure of putative Z-DNA binding protein AF2008 from Archaeoglobus fulgidus, ACA05 W0243 14.