By Vadim A. Ratner, Andrey A. Zharkikh, Nikolay Kolchanov, Sergey N. Rodin, Viktor V. Solovyov, Andrey S. Antonov
In 1970, Manfred Eigen initiated the examine of the beginning of self-reproducing structures of macromolecules and their evolution. Large-scale nucleotide sequencing (with computing device tools) used to be brought from 1977. The authors of this ebook, the 1st variation of which seemed (in Russian) in 1985, were engaged within the study of the evolution of molecular genetic regulatory structures ever considering that these pioneering years. The ebook considers many primary difficulties of molecular biology, evolution, molecular genetic association, the constitution and serve as of macromolecules, continually with the underlying reason of constructing a unified idea. It describes many unique, theoretical effects in addition to computational methods.
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Extra info for Molecular Evolution
2. Hypercycles are capable of evolution through the selection of mutants; this may lead to complexification or simplification, depending on the parameters assigned. 3. Hypercycles can compete with other independent associated assemblies. 4. Internal optimization of hypercycles is possible. 5. Since the hypercycle kinetic equations are a non-linear system (29) in which, under certain conditions, the non-linear terms have powers p > I, selection within these time intervals may be more rigorous and more rapid than exponential substitution.
2 A Minisyser with Two Linked Templates  This is the simplest system (Fig. 7) and lends itself to closer scrutiny. We denote the full concentrations of the fractions as follows: (66) The dynamics of the fractions are described by the standard equations: Xl = alZI - blXl - ,pXt, ill = a2z2 - b2YI - ,pYI, il2 = a3 z2 - b2Y2 - ,pY2, (67) and the quasi-equilibrium conditions for the complexes are given by = (Xl - Zt>(YI - zt>, (Xl - Z2)(Y2 - Z2). (68) The following are sufficient conditions for the existence and local stability of a non-trivial equilibrium point 32 2.
Next we shall consider another possibility, namely the use of cyclic macromolecular assemblies with a universal replication process, and study a number of dynamic properties of these assemblies. 3 Universal Self-Reproducing Systems, Sysers As previously noted in Sect. 1, the core of the MGRS central subsystem has the property of universal self-reproduction (Fig. 1). Specific implementations of these systems are very varied, in other words they make up a large class; however, it is always possible to single out the most important elements of their design that are responsible for self-reproduction.