Download Mechanics of Motor Proteins & the Cytoskeleton by Jonathon Howard PDF

By Jonathon Howard

This article is for biology, biochemistry and chemistry scholars who are looking to find out about the rules of protein mechanics and the way it applies to the morphology and motility of cells. knowing how vehicles and the cytoskeleton function calls for mechanical techniques corresponding to strength, elasticity and damping. Introductory physics textbooks deal with those techniques, but they're involved essentially with macroscopic platforms, whose motions are qualitatively diverse from the hugely damped, diffusive movement of person molecules; this e-book presents a actual starting place for molecular mechanics. half I explains how small debris like proteins reply to mechanical, thermal, and chemical forces, half II makes a speciality of cytoskeletal filaments, and half III makes a speciality of motor proteins. The remedies are unified within the admire that they're equipped round ideas instead of proteins: chapters are established on themes reminiscent of constitution, chemistry, and mechanics, and various filaments or vehicles are mentioned jointly.

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Extra resources for Mechanics of Motor Proteins & the Cytoskeleton

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Howeveq, the velocity of a molecule is correlated over times 'c = m/y. This limits the power at high frequencies and, as a resulf the variance of the thermal force is finite. 3). This equation shows that the root-mean-square thermal force is proportional to the root-mean-square velocity times the damping, in accordance with the notion that the thermal force has the same physical origin as the damping force. Summary Becausemolecules are agitated by collisions with other molecules, they are not always found in their lowest energy state.

The negative sign reflects the tendenry of molecules to move from regions ofhigh concentration to regions of low concentration. The concentration, c, will usually be expressed in units of molecules per cubic meter, though sometimes moles per cubic meter or moles per liter will be used. The flux has units ofr;olecules ler unit area per second, so the diffusion coefficient has units of To derive the diffusion equation we need to relate the flux back to the concentration. 4B. If fewer molecules leave a region to the right than enter it from the left, then there will be a net increase in the concentration in that region.

Witr" tt" aid of Figure35 1d tne fiq; -*ttiit'i. "*tant' CHAPTER ThermalForces ond Diffusion 2,-proteins and cells In addition to the mechanical forces discussed in Chapter with water and otner collisions from arise that forces to thermal subiect are f the the surrounding fluid. ,"t rt sftikes. These collisional forces are called thermal molecules. g). iffryive energy;,as thermal than higher little a only are -llr in", fluctuations thermal and ones' directed q-uitl large comlared to ;;;; It is the noisy, diffustates.

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