Download Lecture Notes by Ian Todd; Gavin Spickett PDF

By Ian Todd; Gavin Spickett

This introductory textual content presents a student-friendly evaluate of crucial immunity and immunopathology themes. Key options are brought in an incremental type to supply an intensive evaluation of the field.

Closely adapted to the undergraduate immunology curriculum, half 1 outlines simple immunology, whereas half 2 covers extra disease-related and scientific points. the recent variation of this well known name incorporates a absolutely up-to-date assessment of the jobs and rules of the cells and molecules of the immune procedure. Key aspect summaries were extended, and key ambitions extra to the beginning of every bankruptcy, to aid the reader concentrate on the basic ‘take-home’ messages. Readers can then try themselves utilizing the new self-assessment part containing problem-solving questions and prolonged matching questions (EMQs).

Including basic, memorable illustrations and fast reference tables, Lecture Notes: Immunology provides the fitting distillation of knowledge for simple bear in mind at revision time, and is perfect for either the beginner and people with a few earlier wisdom of the sphere

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11 There are three major class I molecules (HLA-A, -B and -C) and three major class II molecules (HLA-DP, -DQ and -DR) encoded by genes within the HLA complex on chromosome 6. e. they are polymorphic). Each of them preferentially binds different antigenic peptides, and this causes variation in immune responsiveness to particular antigens between different individuals. 29 Chapter 3 Lymphocyte development and activation Key objectives This chapter will enable you to: 1 Describe the development and selection of B and T lymphocytes in the bone marrow and thymus.

These include the binding of CD2 (expressed by T cells) to CD58, of antigen–antibody complexes inhibit lymphocyte activation. Antibody-secreting plasma cells are end-stage cells and some undergo apoptosis and LFA-1 to intercellular adhesion molecule type 1 (ICAM-1). 1 Examples of pathogen-associated molecular patterns (PAMPs) that interact with Toll-like receptors (TLRs). Type of microbe PAMP Bacterial Lipopolysaccharide Lipoarabinomannan Lipoprotein Peptidoglycan Lipoteichoic acid Flagellin Unmethylated CpG DNA Double-stranded RNA F-protein (respiratory syncytial virus) Zymosan (yeast) Glycophosphoinositol (Trypanosoma cruzi) Viral Fungal Protozoal 38 inating an invading antigen being overshadowed by unacceptable damage to self tissues (see Chap- tence of circulating antibodies specific for previously encountered antigens.

These include the binding of CD2 (expressed by T cells) to CD58, of antigen–antibody complexes inhibit lymphocyte activation. Antibody-secreting plasma cells are end-stage cells and some undergo apoptosis and LFA-1 to intercellular adhesion molecule type 1 (ICAM-1). 1 Examples of pathogen-associated molecular patterns (PAMPs) that interact with Toll-like receptors (TLRs). Type of microbe PAMP Bacterial Lipopolysaccharide Lipoarabinomannan Lipoprotein Peptidoglycan Lipoteichoic acid Flagellin Unmethylated CpG DNA Double-stranded RNA F-protein (respiratory syncytial virus) Zymosan (yeast) Glycophosphoinositol (Trypanosoma cruzi) Viral Fungal Protozoal 38 inating an invading antigen being overshadowed by unacceptable damage to self tissues (see Chap- tence of circulating antibodies specific for previously encountered antigens.

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