Download Le dépistage du cancer colorectal : État des lieux et by Étienne Dorval PDF

By Étienne Dorval

Cet ouvrage fait le aspect sur le rationnel scientifique et l’?tat des lieux du d?pistage organis? du melanoma colorectal en France. Il est aussi l’occasion d’aborder les ideas et les strat?gies ?mergentes qui pourront contribuer ? l’am?lioration des r?sultats de ce d?pistage si elles font los angeles preuve de leur sup?riorit? sur los angeles strat?gie actuelle.

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Additional resources for Le dépistage du cancer colorectal : État des lieux et perspectives (Dépistage et cancer)

Sample text

Dans une autre étude (45), des sujets asymptomatiques à risque moyen de cancer colorectal, qui avaient subi une polypectomie d’un ou plusieurs adénomes, ont été comparés aux contrôles chez lesquels l’incidence du cancer colorectal avait été estimée à partir des taux de mortalité par cancer colorectal extraits des registres nationaux italiens. Cette comparaison a montré une réduction significative de 66 % (IC 95 %, 0,23-0,63) de l’incidence du cancer colorectal après 10,5 ans de surveillance postpolypectomie.

La même année, le Collège Américain de Gastroentérologie s’est prononcé en faveur de la CT pratiquée tous les dix ans à partir de 50 ans et a proposé comme alternative un test Hemoccult II® annuel et une RSS tous les cinq ans (5). Les recommandations australiennes proposent soit la CT tous les cinq à dix ans soit un test Hemoccult II® annuel associé à une RSS tous les cinq ans (6). En 2003, l’Association Américaine de Gastroentérologie (7) a proposé aux sujets à risque moyen âgés de 50 ans ou plus de choisir parmi les stratégies de dépistage suivantes: a) test Hemoccult II® annuel (trois tests à deux reprises associés à des restrictions diététiques et sans réhydratation) ; b) une RSS tous les cinq ans suivie de CT si la première investigation a démontré la présence d’adénome de plus d’un centimètre, d’adénome villeux, d’adénomes multiples ou d’autre type d’adénome chez un patient de plus de 65 ans ou ayant un contexte familial de cancer colorectal ; c) test Hemoccult II® annuel suivi de RSS tous les cinq ans, en commençant par le test Hemoccult II® ; ou d) une CT tous les dix ans.

J Natl Cancer Inst 84: 1572-5 13. Traverso G, Shuber A, Levin B et al. (2002) Detection of APC mutations in fecal DNA from patients with colorectal tumors. N Engl J Med 346: 311-20 14. Albaugh GP, Iyengar V, Lohani A et al. (1992) Isolation of exfoliated colonic epithelial cells, a novel, non-invasive approach to the study of cellular markers. Int J Cancer 52: 347-50 15. Limburg PJ, Ahlquist DA, Gilbert JA et al. (2000) Immunodiscrimination of colorectal neoplasia using MUC1 antibodies: discrepant findings in tissue versus stool.

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