By Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee
This 8th and ultimate record of the Immunization security assessment Committee examines the speculation that vaccines, in particular the measles-mumps-rubella (MMR) vaccine and thimerosal-containing vaccines, are causally linked to autism. The committee reviewed the extant released and unpublished epidemiological reviews relating to causality and reports of capability biologic mechanisms through which those immunizations could reason autism. Immunization safeguard evaluate: Vaccines and Autism unearths that the physique of epidemiological facts favors rejection of a causal dating among thimerosal-containing vaccines and autism. The publication additional unearths that capability organic mechanisms for vaccine-induced autism which have been generated up to now are just theoretical. It recommends a public wellbeing and fitness reaction that absolutely helps an array of vaccine protection actions and recommends that on hand investment for autism examine be channeled to the main promising parts. The e-book makes extra options relating to surveillance and epidemiological examine, medical experiences, and communique concerning those vaccine safeguard concerns.
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Extra resources for Immunization Safety Review: Vaccines and Autism
Thus the committee concluded in its third report (IOM, 2002b) that for future reports, the lack of clarity in the phrase “biological plausibility” warranted the adoption of new terminology and a new approach to its discussion of biological data. The committee decided to review evidence regarding “biological mechanisms” that might be consistent with the proposed relationship between a vaccine exposure and given adverse events. The biological mechanisms section of the report is written distinct from any argument regarding the causality of such relationships.
932 = 65 µg. 27 kg. Females were selected because their smaller body weight makes them more susceptible than males. 3 µg/kg body weight/week. For calculations, daily limits multiplied by 7 to obtain weekly limits. NOTE: Data were bolded by the IOM, not by the original authors of the table. EPA: Environmental Protection Agency; ATSDR: Agency for Toxic Substances and Disease Registry; FDA: Food and Drug Administration; WHO: World Health Organization. , 2001. Reprinted with permission from Pediatrics 107:1150, Table 1, Copyright 2001.
The first report, which reviewed the hypothesized causal association between the MMR vaccine and autism (IOM, 2001a), the committee concluded that the evidence at the time favored rejection of a causal relationship at the population level between MMR vaccine and autism. The committee’s conclusion did not exclude the possibility that MMR could contribute to autism in small number of children, given that the epidemiological studies lacked sufficient precision to assess rare occurrences. Thus it was possible that epidemiological studies would not detect a relationship between autism and MMR vaccination in a subset of the population with a genetic predisposition to autism.