Download Human Cancer Markers by William C. Raschke (auth.), Stewart Sell, Britta Wahren PDF

By William C. Raschke (auth.), Stewart Sell, Britta Wahren (eds.)

The skill to diagnose melanoma by means of easy size of a serum or tissue' 'marker" has been a aim of clinical technological know-how for a few years. there's considerable facts that tumor cells are assorted from basic cells and seasoned­ duce elements that may be detected through presently on hand immuno­ chemical or biochemical equipment. those "cancer markers" can be se­ creted proteins, enzymes, hormones, fetal serum parts, monoclonal immunoglobulins, phone floor elements, or cytoplasmic materials. the aim of this e-book is to offer the present prestige of our wisdom of such melanoma markers. the 1st tumor marker pointed out by way of laboratory ability used to be Bence­ Jones protein. In a sequence of lectures dropped at the Royal collage of Phy­ sicians in London in 1846, Dr. H. Bence Jones defined experiences on a urine pattern despatched to him with the next be aware: "Dear Dr. Jones-The tube includes urine of very excessive particular gravity. while boiled it turns into a bit of opaque . . . . and so forth. " Dr. Jones discovered that heating of the urine after addition of nitric acid led to formation of a heavy precipitate; acid advert­ dition can have been required to convey the urine to pH 4-6 at which Bence Jones proteins usually tend to precipitate whilst heated. This urinary pre­ cipitate was once linked to a bone ailment termed "mollities ossium. " [H. Bence Jones, Papers on Chemical Pathology, Lecture III. Lancet 2, 269-274 (1847)].

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