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APMIS Suppl 1998;80:1-41. 41. Clifford GM, Smith JS, Plummer M, et al: Human papillomavirus types in invasive cervical cancer worldwide: A meta-analysis. Br J Cancer 2003;88:63-73. 42. Swan DC, Tucker RA, Tortolero-Luna G, et al: Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type. J Clin Microbiol 1999;37:1030-1034. 43. Hildesheim A, Wang SS: Host and viral genetics and risk of cervical cancer: A review [review]. Virus Res 2002;89:229-240. 44. Wang SS, Hildesheim A: Viral and host factors in human papillomavirus persistence and progression [review].

Int J Cancer 1998;76:613-619. 70. Deacon JM, Evans CD, Yule R, et al: Sexual behaviour and smoking as determinants of cervical HPV infection and of CIN3 among those infected: A case-control study nested within the Manchester cohort. Br J Cancer 2000;83:1565-1572. 71. Castle PE, Wacholder S, Lorincz AT, et al: A prospective study of high-grade cervical neoplasia risk among human papillomavirus-infected women. J Natl Cancer Inst 2002;94:1406-1414. 72. Moodley M, Moodley J, Chetty R, Herrington CS: The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: A review [review].

Ongoing and future molecular epidemiologic studies will increase understanding of the role of these cofactors and the identification of the biologic mechanisms involved in the carcinogenesis process. This will require the use and development of new molecular tools and novel statistical modeling approaches to understand mechanisms in the natural history of HPV and cervical cancer. , HPV DNA and serologic markers). These studies will need to be large, multicenter, and multidisciplinary to allow for the study of diverse populations in terms of age, race/ethnicity, and geographic distribution.

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