By Brian H. Vickery, Bruno Lunenfeld (auth.), B. H. Vickery, B. Lunenfeld (eds.)
These 4 volumes comprising "GnRH Analogues in melanoma and Human copy" are a distillation of the shows of the invited audio system at a landmark foreign Symposium bearing an identical identify, equipped by means of one in all us (B. L. ) and held in Geneva, Switzerland in February 1988. The Symposium used to be actually interdisciplinary spanning gonadal hormone based sickness together with a variety of kinds of melanoma and varying to regulate of fertility, either professional- and perception. The overseas style could be stuck from the 480 members and 259 members drawn from 14 nations. The Symposium, and consequently this publication, do not have been attainable with no the backing of The foreign Committee for examine in copy and the sponsorship of the overseas Society of Gynecologic Endocrinology, The Swiss Society of Fertility and Sterility, The college of Geneva university of medication, The Swiss Society of Endocrinology and the U.S. starting place for stories in copy Inc. , and support from the area future health association. B. H. Vickery B. Lunenfeld June 1989 checklist OF members TO THE sequence H. Bartermann A. Abbondante First Institute of Obstetrics and Urologische Universitatsklinik Kiel Gynecology Arnold-Heller Strasse 7 college "La Sapienza" D-2300 Kiel 1, FRG Rome,ltaly M. Bartholomew P. Abel division of Medicine/Endocrinology division of Urology Milton S. Hershey scientific heart Hammersmith health center Pennsylvania country college DuCane street PO field 850, Hershey, PA 17033, united states London W12 OHS, united kingdom D. Beck H.
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Extra resources for GnRH Analogues in Cancer and Human Reproduction: Volume IV Precocious Puberty, Contraception and Safety Issues
A transient rise in serum LH and testosterone after each buserelin injection despite low basal serum of testosterone secretion is found throughout 12 months of treatment. In the safety evaluation, it should be considered that in rats, a delay in pubertal maturation is required for only 8 weeks. The specific reactions of steroid biosynthesis to buserelin in rats differ greatly from those observed in the human, where no steroidogenic lesions are detected . The effects of buserelin on spermatogenesis in dogs and monkeys would seem more relevant.
Androgen biosynthesis in Leydig cells after testicular desensitization by luteinizing hormone-releasing hormone and human chorionic gonadotropin. Endocrinology, 105, 1314 29. Damber, J~Bergh, A and Daehlin, L (1984). Stimulatory effect of an LHRH-agonist on testicular blood flow in hypophysectomized rats. Int J Androl, 7, 236 30. Sandow, J, Fraser, HM, Seidel, H,-Krauss, B, Jerabek-Sandow, Gand Rechenberg, Wv (1987). Buserelin: pharmacokinetics, metabolism and mechanisms of action. Brit J Clin Pract, il (Suppl 48), 6 31.
In one animal, about 3/4 of the testis contained atrophic tubuli seminiferi. -------/0 I 7 I 11 weeks of age I 15 I 19 FIGURE 1 Inhibition of pubertal maturation in male rats. response to buserelin treatment injections at 3. 7 and 11 weeks of age. The basal serum testosterone is much lower in buserelin treatment animals than in age-matched controls. During th~ recovery period after buserelin treatment. normal serum testosterone secretion is resumed. In control rats. full spermatogenesis is present at 7 weeks of age.