Download Genetically Engineered Mice for Cancer Research: design, by Thomas Doetschman, L. Philip Sanford (auth.), Jeffrey E. PDF

By Thomas Doetschman, L. Philip Sanford (auth.), Jeffrey E. Green, Thomas Ried (eds.)

Genetically-engineered mouse types for melanoma study became beneficial instruments for learning melanoma biology and comparing novel healing methods. This quantity specializes in cutting-edge equipment for producing, studying and validating such types for learning points of human melanoma biology. also, those types are rising as vital pre-clinical platforms during which to check melanoma prevention and healing techniques with the intention to decide on compounds for trying out in medical trials.

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Extra resources for Genetically Engineered Mice for Cancer Research: design, analysis, pathways, validation and pre-clinical testing

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Nucleic Acids Res 34:1416–1426 Deng C (2007) In celebration of Dr Mario R. Capecchi’s Nobel Prize. Int J Biol Sci 3:417–419 Deng CX, Wang RH (2003) Roles of BRCA1 in DNA damage repair: a link between development and cancer. Hum Mol Genet 12:R113–R123 Deng CX, Xu X (2004) Generation and analysis of Brca1 conditional knockout mice. Methods Mol Biol 280:185–200 Deng C, Thomas KR, Capecchi MR (1993) Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol 13:2134–2140 Derynck R, Akhurst RJ, Balmain A (2001) TGF-beta signaling in tumor suppression and cancer progression.

Cell 59:499–509 Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH (1996) Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet 12:191–194 Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H (2001) Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294:2186–2189 Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting [see comments].

Curr Opin Oncol 11:435–441 Argos P, Landy A, Abremski K, Egan JB, Haggard-Ljungquist E, Hoess RH, Kahn ML, Kalionis B, Narayana SV, Pierson LS 3rd et al (1986) The integrase family of site-specific recombinases: regional similarities and global diversity. EMBO J 5:433–440 Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA (2006) Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.

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