Download Genetic Predisposition to Cancer by D. Timothy Bishop (auth.), Rosalind A. Eeles, Bruce A. J. PDF

By D. Timothy Bishop (auth.), Rosalind A. Eeles, Bruce A. J. Ponder, Douglas F. Easton, Alan Horwich (eds.)

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29-30). It is important to note that these P-values are not necessarily a good approximation in small samples [19]. For example, a LaO score of 3 can be obtained using 10 scorable phase known meiosis, if all 10 are consistent with linkage, which would occur by chance with probability 11210 or about 1 in 1000. If necessary 'exact' P-values can be obtained by simulation [20]. 2 illustrates some examples of LaO score calculations in simple families. e. all individuals with the gene develop the disease).

5 ovarian and bowel cancer. There is - and will be - long-running debate about the importance of genes for such syndromes in terms of the proportion of all cancer that is directly attributable to such predisposition. Finally, the evidence that relatives of cases of a particular cancer have an increased risk of the same cancer suggests that genetic susceptibility could play a role in a large proportion of all cancers. The speculation is that, unlike the rare syndromes associated with a high risk of cancer and for which there is no evidence that manipulation of other environmental exposures could affect the occurrence of cancer, some form of modification may be relevant for individuals with a modestly increased genetically determined risk of cancer.

1993) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell, 75, 1027-38. 40. , Papadopoulos, N. et al. (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell, 75, 1215-25. 41. E. (1980) An inherited form of large bowel cancer. Muir's syndrome. Cancer, 45(suppl. 5), 1103-7. 42. , Werelius, B. and Nordenskj61d, M. (1993) Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. , 5(3), 279--82.

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