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By G. Röhrborn (auth.), Dr. Philip L. Chambers, Professor Dr. Wolfgang Klinger (eds.)

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Read Online or Download Further Studies in the Assessment of Toxic Actions: Proceedings of the European Society of Toxicology Meeting, Held in Dresden, June 11 – 13, 1979 PDF

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Additional resources for Further Studies in the Assessment of Toxic Actions: Proceedings of the European Society of Toxicology Meeting, Held in Dresden, June 11 – 13, 1979

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The females were killed 20 h after the implantation of the BrdU tablet. 005% colcemide solution. Abbreviations: CP = cyclophosphamide, MMS = methyl metanesuifonate. C. Environmental Research Programme 23 Sister Chromatid Exchanges in Chinese Hamster Embryonic Through cutting and pipetting a cell suspension was obtained. The cells were incubated for 2 h in a CO 2 incubator at 37° C. 5, chromosome preparations were made in the conventional way. Differential staining of chromatids was carried out with Hoechst 33258 dye and Giemsa.

Induction of tumors in rats by postnatal (I), transplacental (II), or combined transplacental and postnatal (III) administration of procarbazine (Natulan) Group Mode of application No. of rats No. of rats with tumors No. w. w. w. w. iv intervals of 2 weeks mentioned conclusions need further precision and that transplacental carcinogenicity can evidently be influenced by factors which require further investigations. In a first series of experiments we studied the carcinogenicity of procarbazine (Natulan R ) in Hooded rats (Table 1).

Introduction There is argument about which kind of screening method is the most reliable and practical in order to detect hazardous chemicals such as mutagens or carcinogens in our environment. Several hundred compounds have been already tested by microbial test systems particulary as proposed by Ames et al. (1973), with approximately 85% correlation between mutagenicity and carcinogenicity. Recently, the Ames test system using 6 different strains of bacteria was proposed by the Ministry of Labour in Japan for an evaluation of the safety on the main products from industries.

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