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By Alfred A. Bove (Eds.)

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Saunders, Philadelphia, Pennsylvania. 11. Haddy, F. , and Scott, J. B . (1968). Physiol. Rev. 4 8 , 6 8 8 - 7 0 7 . 12. , Dickhuth, Η. H . , Simon, G . , and Lehmann, M. (1981). Circ. Res. 48, Suppl. 1, 162-170. 13. Newman, G. F . , Rerych, S. , Upton, M . T . , Sabiston, D. , and Jones, R. H. (1980). Circulation 6 2 , 1 2 0 4 - 1 2 1 1 . 14. Rowell, L. B . (1974). Physiol. Rev. 5 4 , 7 5 - 1 5 9 . 15. Rushmer, R. F. (1959). Am. J. Physiol. 196, 7 4 5 - 7 5 0 . 16. Rushmer, R. F . , and Smith, O.

Engl. J. Med. 297, 1 9 4 - 2 0 1 . 17. Wasserman, K. (1978). Breathing during exercise. N. Engl. J. Med. 298, 7 8 0 - 7 8 5 . 18. Dejours, P. (1965). Control of respiration in muscular exercise. In "Handbook of Physiology" (W. O. Fenn and H. ), Sect. 3 , Vol. 1, pp. 6 3 1 - 6 4 8 . Am. Physiol. S o c , Washington, D . C . 19. Farber, J. P . , and Bedell, G. N. (1973). Responsiveness of breathing control centers to C 0 2 and neurogenic stimuli. Respir. Physiol. 19, 8 8 - 9 5 . 20. , Rasmussen, B .

The relationship of minute ventilation (VE), oxygen consumption ( V o 2) , and carbon dioxide production ( V c o 2) to work. Note that whereas oxygen consumption increases linearly, C 0 2 production and minute ventilation increase more rapidly relative to work when anaerobic metabolism occurs. 4 thoracic mechanoreceptors, the medullary respiratory center, and a 'missing link" (17). It is instructive to examine the steady-state response to exercise, described by DeJours and others as having two phases (18).

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