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By Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council, Commission on Life Sciences

Document of the Subcommittee on Reproductive and Developmental Toxicology of urged methods that may be used to judge chemical compounds and actual brokers for his or her strength to reason reproductive and developmental toxicology and the way those ways can be utilized through the military. Softcover.

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Extra info for Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity

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Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution. 1 As it is described and expanded on in the subcommittee's report, the process undertakes a systematic review of data on reproductive and developmental toxicity in humans and experimental animals, on general toxicity, and on the conditions of use that result in human exposure.

1996). In assessing reproductive and developmental toxicity, a spectrum of endpoints in adult men and women, embryos, fetuses, infants, and children need to be considered. Reproductive outcomes are typically measures related to fertility (the ability to conceive) and fecundity. , a pregnancy occurring elsewhere than in the uterus), and premature reproductive senescence. , spontaneous abortions, still births, and infant deaths), birth defects, altered growth, Copyright © National Academy of Sciences.

1995a; California Environmental Protection Agency 1991). Each agency or organization has established criteria for evaluating data on the reproductive and developmental effects of exposures to agents, as summarized in Table 1-1. The International Programme on Chemical Safety (IPCS) (1994) identified current differences in risk assessment procedures for reproductive and developmental toxicity among several countries. IPCS also has proposed ways to improve the international harmonization of those procedures.

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