By John F.R. Robertson, Robert I. Nicholson, Daniel F. Hayes
This article stories the newest principles in tumor biology, explains the pharmacologic foundation of the brokers used, and discusses how they're utilized in scientific perform. half One offers an summary of the scientific value of endocrine treatment, and describes the purposes of the valuable sessions of gear, together with antiestrogens, aromatase inhibitors, progestins, and progesterone receptor antagonists. This part additionally discusses ovarian ablation. half offers with the organic facets of endocrine remedies, and relates present figuring out of tumor biology and the pharmacologic foundation of hormonal brokers to their scientific purposes. one of the issues coated are resistance and sensitivity to treatment. half 3 outlines destiny thoughts, specifically using blend endocrine remedy, adjuvant development issue remedy and using anti-invasive brokers. this article is key for oncologists and pharmacologists alike.
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Additional resources for Endocrine Therapy of Breast Cancer
Clin Endocrinol 1987; 26: 213–20. Gallen M, Alonso MC, Ojeda B et al. Randomized multicentre trial comparing two different timespans of adjuvant tamoxifen therapy (ATT) in women with operable node positive breast cancer. Proc Am Soc Clin Oncol 1994; 13: 76. Swedish Breast Cancer Cooperative Group. Randomized trial of 2 versus 5 years of adjuvant tamoxifen in postmenopausal early-stage breast cancer. Proc Am Soc Clin Oncol 1996; 15: 126. Colditz GA, Willett WC, Stampfer MJ. Menopause and the risk of coronary heart disease in women.
Boston: Hall, 1981: 83–9. 45. Ludwig Breast Cancer Study Group. Adjuvant combination chemotherapy with or without prednisone in premenopausal breast cancer patients with metastases in 1 to 3 axillary lymph nodes: a randomized trial. Cancer Res 1985; 45: 4454–9. 46. Bonadonna G, Valagussa P, DePalo G. The results of adjuvant chemotherapy are predominantly caused by the hormonal changes such therapy induces. In: Medical Oncology. Controversies in Cancer Treatment (Van ScoyMoscher MB, ed). Boston: Hall, 1981: 100–9.
25. 26. 27. 28. 29. 30. ENDOCRINE THERAPY OF BREAST CANCER LHRH-agonist (LHRH-A) ϩ tamoxifen (TAM) versus LHRH-A alone in premenopausal women with advanced breast cancer (ABC): results of a meta-analysis of four trials. Proc Am Soc Clin Oncol 1999; 18: 110a. Klijn J, Blamey R, Boccardo F et al. A new standard treatment for advanced premenopausal breast cancer: a meta-analysis of the combined hormonal agent trialists’ group (CHAT). Eur J Cancer 1998; 345: 405. Fisher B, Slack NH. Number of lymph nodes examined and the prognosis of breast carcinoma.