Download Drug Resistance in Cancer Therapy by Robert C. Young (auth.), Robert F. Ozols M.D., Ph.D. (eds.) PDF

By Robert C. Young (auth.), Robert F. Ozols M.D., Ph.D. (eds.)

Where do you start to appear for a up to date, authoritative article at the prognosis or administration of a selected malignancy? The few common oncology textbooks are in most cases old-fashioned. unmarried papers in really good journals are informative yet seldom finished; those are extra usually initial stories on a truly constrained variety of sufferers. definite normal journals often put up reliable in-depth studies of melanoma issues, and released symposium lectures are frequently the simplest overviews on hand. Unfor­ tunately, those reports and vitamins seem sporadically, and the reader can by no means verify while an issue of exact curiosity might be coated. melanoma therapy and study is a chain of authoritative volumes that objective to fulfill this want. it truly is an try and determine a severe mass of oncology literature protecting nearly all oncology themes, revised usually to maintain the insurance brand new, simply on hand on a unmarried library shelf or by way of a unmarried own subscription. we now have approached the matter within the following model: first, by means of dividing the oncology literature into particular subdivisions comparable to lung can­ cer, genitourinary melanoma, and pediatric oncology; moment, via asking emi­ nent specialists in every one of those components to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor variety is roofed in a quantity showing usually and predictably, discussing present prognosis, staging, markers, all sorts of therapy modalities, simple biology, and more.

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Levin, L. M. (1977). Dose intensity analysis of chemotherapy regimens in ovarian cancer. J. Clin. Oncol. 5:756-769. 27. J. H. (1988). Impact of dose-intense chemotherapy on the development of permanent drug resistance. Seminars in Oncology, in press. 28. L. H. (1988). Models of dose intensity, submitted. 29. H. J. (1983). Clinical implications of the phenomenon of drug resistance. In Drug and Hormone Resistance in Neoplasia, eds. Bruchovsky, N. , Boca Raton, vol. II, pp. 111-127. 30. A. B. (1988).

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Boca Raton, vol. II, pp. 111-127. 30. A. B. (1988). A Mathematical and computer based model of alternating chemotherapy and radiation therapy in experimental neoplasms. , in press. 26 3. Multidrug resistance in human tumors Antonio T. Fojo Resistance to multiple, structurally unrelated chemotherapeutic agents remains a major obstacle to successful cancer chemotherapy. In an attempt to develop in vitro models for the study of drug resistance, workers in several laboratories, using Adriamycin, actinomycin D, the vinca alkaloids, or colchicine as single agents in the selection of human and rodent cell lines, have isolated cell lines having the multidrug resistance phenotype [1-8].

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