Download Cancer Stem Cells in Solid Tumors by Christopher R. Cogle (auth.), Alison L. Allan (eds.) PDF

By Christopher R. Cogle (auth.), Alison L. Allan (eds.)

The “cancer stem mobilephone” speculation postulates that melanoma arises from a subpopulation of tumor-initiating cells or melanoma stem cells (CSCs). whereas the assumption of melanoma stem cells has been round for greater than 100 years, facts from the fields of hematology and melanoma biology has now tested the serious position of stem cells in hematological malignancies and prompt that those comparable mechanisms also are relevant to the initiation, development, and remedy of good cancers. scientific and experimental reports have proven that CSCs express many classical homes of ordinary stem cells, together with a excessive self-renewal potential and the facility to generate heterogeneous lineages; the requirement for a selected “niche”/microenvironment to develop; and an elevated capability for self-protection opposed to harsh environments, pollution, and medication.

Cancer Stem Cells in sturdy Tumors represents a close assessment of melanoma stem cells and their function in stable cancers. constituted of 24 chapters, this quantity will offer readers with a finished realizing of this crucial and evolving field.

Topics lined include:

  • Introduction of the CSC hypothesis
  • Historical views and the contributing classes from leukemia
  • Current wisdom in regards to the id and position of CSCs in a number of types of sturdy melanoma together with breast, mind, colorectal, pancreatic, prostate, cancer, lung, ovarian, hepatocellular, and head and neck melanoma
  • Molecular pathways inquisitive about using CSC functionality, with a specific specialize in the radical convergence of embryonic and tumorigenic signaling pathways
  • In vitro and in vivo assays, version platforms, and imaging modalities for learning CSCs
  • The medical value of CSCs for melanoma administration and therapy, together with very important implications for analysis, prediction, and remedy resistance
  • Consideration of the debate surrounding the CSC speculation and significant unanswered questions during this field

This collective paintings was once written via a gaggle of renowned overseas specialists in melanoma biology, oncology, and/or stem cellphone biology. it is going to function a necessary source for tested researchers, professors, future health care execs, and scholars within the clinical and medical group who're investigating stem cells and/or oncology.

Show description

Read Online or Download Cancer Stem Cells in Solid Tumors PDF

Similar cancer books

When Breath Becomes Air

Contributor word: ahead by way of Abraham Verghese

For readers of Atul Gawande, Andrew Solomon, and Anne Lamott, a profoundly relocating, exquisitely saw memoir via a tender neurosurgeon confronted with a terminal melanoma analysis who makes an attempt to respond to the query What makes a existence worthy living?

At the age of thirty-six, at the verge of finishing a decade’s worthy of teaching as a neurosurgeon, Paul Kalanithi used to be clinically determined with degree IV lung melanoma. in the future he was once a physician treating the loss of life, and the subsequent he was once a sufferer suffering to reside. And similar to that, the long run he and his spouse had imagined evaporated.

When Breath turns into Air chronicles Kalanithi’s transformation from a naïve clinical pupil “possessed,” as he wrote, “by the query of what, on condition that all organisms die, makes a virtuous and significant life” right into a neurosurgeon at Stanford operating within the mind, the main severe position for human id, and eventually right into a sufferer and new father confronting his personal mortality.

What makes existence worthy residing within the face of demise? What do you do while the long run, now not a ladder towards your ambitions in existence, flattens out right into a perpetual current? What does it suggest to have a toddler, to nurture a brand new lifestyles as one other fades away? those are a few of the questions Kalanithi wrestles with during this profoundly relocating, exquisitely saw memoir.

Paul Kalanithi died in March 2015, whereas engaged on this publication, but his phrases live to tell the tale as a advisor and a present to us all. “I started to discover that coming nose to nose with my very own mortality, in a feeling, had replaced not anything and everything,” he wrote. “Seven phrases from Samuel Beckett started to repeat in my head: ‘I can’t move on. I’ll pass on. ’” whilst Breath turns into Air is an unforgettable, life-affirming mirrored image at the problem of dealing with dying and at the dating among healthcare professional and sufferer, from a super author who grew to become either.

Cell Cycle Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)

Major clinicians and investigators assessment in a understandable and hassle-free sort the entire newest information regarding the molecular biology of cellphone cycle keep an eye on and reveal its medical relevance to knowing neoplastic ailments. subject matters diversity from Cdk inhibitors and cellphone cycle regulators to the prognostic worth of p27 and tumor suppressor genes as diagnostic instruments.

Cancer of the Prostate and Kidney

This booklet is the list of the court cases of a NATO complicated learn Institute held in Erice, Sicily, from the second - twelfth June 1981, within which scientists and clinicians drawn to the issues awarded by means of melanoma of the kidney and the prostate have been inspired to give, to debate and to problem the critiques expressed and the ideals held by means of the various members.

Additional info for Cancer Stem Cells in Solid Tumors

Sample text

These observed levels of heterogeneity are accounted for by the cancer stem cell (CSC) hypothesis, which postulates that cancers are hierarchically organized stemming from progenitor cells, or CSCs [18]. The hierarchal nature of the tumors mirrors that of the normal breast tissue for which a normal mammary epithelial stem cell (MaSC) has recently putatively been identified in human and murine tissues. 2 Normal Breast Organization and Mammary Stem Cells Recent studies point strongly to the existence of both murine and human MaSCs.

Tumor cells able to initiate and maintain colony growth in the secondary sites form micrometastases, which, following angiogenesis, progress to macrometastases [94, 96, 97]. Although tumor cells may readily escape the primary tumor and enter circulation, production of sustainable metastatic lesions is a highly inefficient process (reviewed by Hunter et al. [98]). This was exemplified by an in vivo videomicroscopy study by Luzzi et al. 02% of melanoma cells injected to target the liver could successfully complete the metastatic cascade [99].

L. Allan 16. Lobo NA, Shimono Y, Qian D, Clarke MF (2007) The biology of cancer stem cells. Annu Rev Cell Dev Biol 23:675–699. 104154 17. McDermott SP, Wicha MS (2010) Targeting breast cancer stem cells. Mol Oncol. 005 18. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Stem cells, cancer, and cancer stem cells. Nature 414 (6859):105–111. 1038/35102167 35102167 [pii] 19. Smith GH, Chepko G (2001) Mammary epithelial stem cells. Microsc Res Tech 52 (2):190–203. , Bern HA, Blair PB (1959) Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female c3h mice.

Download PDF sample

Rated 4.39 of 5 – based on 33 votes