By Christopher R. Cogle (auth.), Alison L. Allan (eds.)
The “cancer stem mobilephone” speculation postulates that melanoma arises from a subpopulation of tumor-initiating cells or melanoma stem cells (CSCs). whereas the assumption of melanoma stem cells has been round for greater than 100 years, facts from the fields of hematology and melanoma biology has now tested the serious position of stem cells in hematological malignancies and prompt that those comparable mechanisms also are relevant to the initiation, development, and remedy of good cancers. scientific and experimental reports have proven that CSCs express many classical homes of ordinary stem cells, together with a excessive self-renewal potential and the facility to generate heterogeneous lineages; the requirement for a selected “niche”/microenvironment to develop; and an elevated capability for self-protection opposed to harsh environments, pollution, and medication.
Cancer Stem Cells in sturdy Tumors represents a close assessment of melanoma stem cells and their function in stable cancers. constituted of 24 chapters, this quantity will offer readers with a finished realizing of this crucial and evolving field.
Topics lined include:
- Introduction of the CSC hypothesis
- Historical views and the contributing classes from leukemia
- Current wisdom in regards to the id and position of CSCs in a number of types of sturdy melanoma together with breast, mind, colorectal, pancreatic, prostate, cancer, lung, ovarian, hepatocellular, and head and neck melanoma
- Molecular pathways inquisitive about using CSC functionality, with a specific specialize in the radical convergence of embryonic and tumorigenic signaling pathways
- In vitro and in vivo assays, version platforms, and imaging modalities for learning CSCs
- The medical value of CSCs for melanoma administration and therapy, together with very important implications for analysis, prediction, and remedy resistance
- Consideration of the debate surrounding the CSC speculation and significant unanswered questions during this field
This collective paintings was once written via a gaggle of renowned overseas specialists in melanoma biology, oncology, and/or stem cellphone biology. it is going to function a necessary source for tested researchers, professors, future health care execs, and scholars within the clinical and medical group who're investigating stem cells and/or oncology.
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Additional info for Cancer Stem Cells in Solid Tumors
These observed levels of heterogeneity are accounted for by the cancer stem cell (CSC) hypothesis, which postulates that cancers are hierarchically organized stemming from progenitor cells, or CSCs . The hierarchal nature of the tumors mirrors that of the normal breast tissue for which a normal mammary epithelial stem cell (MaSC) has recently putatively been identified in human and murine tissues. 2 Normal Breast Organization and Mammary Stem Cells Recent studies point strongly to the existence of both murine and human MaSCs.
Tumor cells able to initiate and maintain colony growth in the secondary sites form micrometastases, which, following angiogenesis, progress to macrometastases [94, 96, 97]. Although tumor cells may readily escape the primary tumor and enter circulation, production of sustainable metastatic lesions is a highly inefficient process (reviewed by Hunter et al. ). This was exemplified by an in vivo videomicroscopy study by Luzzi et al. 02% of melanoma cells injected to target the liver could successfully complete the metastatic cascade .
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