By Valda M. Craddock
The ebook offers in brief with the conventional constitution, functioning and biochemistry of the esophagus and with the histological and genetic adjustments accompanying the improvement of esophageal melanoma in people and animals. elements implicated in inflicting esophageal melanoma are defined with regards to its very dramatic epidemiology. therefore nutritional deficiencies and intake of meals infected by means of Fusaria mycotoxins are mentioned in reference to the tremendous excessive occurrence of the ailment in yes sharply demarcated areas in China and South Africa, and alcohol and tobacco use are mentioned with regards to the epidemiology in Europe and united states. different risks pointed out comprise opium in Iran, betel nut in Asia and bracken in Japan. the only staff of chemical compounds identified to be very effective esophageal cancer agents in animal experiments, the nitrosamines, are defined specifically by way of the frequent human publicity.
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Additional info for Cancer of the Esophagus: Approaches to the Etiology (Cambridge Monographs on Cancer Research)
10, 159-170. The light and electron microscopic distribution of acid phosphatase activity in human esophageal epithelium. L. F. L. ) New York: McGraw-Hill, pp. 247-307. Anatomy. E. (1952) /. Anat. 86, 431-442. Developmental changes in the esophageal epithelium of man. Lazarides, E. (1982) Ann. Rev. Biochem. 51, 519-550. Intermediate filaments: a chemically homogeneous, developmentally regulated class of proteins. C. M. (1964) In: Advances in Biology of Skin, vol. 5, Wound Healing (Montagna, W. E.
Baltimore: University Park Press, pp. 315-329. Naturally-occurring inhibitors of chemical carcinogens. Esophageal carcinogenesis High-risk diseases A number of diseases, not only those directly affecting the esophagus, are associated with an increased risk of esophageal cancer. 1) include chronic esophagitis, stricture, certain motility diseases, reflex esophagitis, Barrett's esophagus, Plummer-Vinson syndrome, celiac diseases, and tylosis. Chronic esophagitis is sometimes considered to be an essential precursor lesion for esophageal cancer in man, and is more conveniently discussed in the following section where the precursor lesions are considered.
Esophagus from a rat on day 7 following two doses of 2 mg/kg NMBzA. The basal layer is disrupted and there is a mixed inflammatory infiltrate in the submucosa extending into the epithelium. H&E, x 80. (From Craddock et al. ) 34 Esophageal carcinogenesis been detected. This is possibly a result of the lack of protection of the mucosa either by mucus secretion or by keratinization (see Chapter 2). There is only one report of the apparently experimental production by NDEA of esophageal papillomas in a cat (Schmahl et al.