By Israel Penn (auth.), J. L. Touraine, J. Traeger, H. Bétuel, J. M. Dubernard, J. P. Revillard, C. Dupuy (eds.)
Malignancies are common problems in organ transplantation, generally because the results of an infection with yes viruses and of long term immunosuppression. The epidemiology confirms that the elevated prevalence issues yes cancers, particularly HIV-related dermis cancers and EBV-related lymphoproliferative malignancies.
This publication covers all at the moment on hand info in this very important subject of the relationships among transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and therapy. an important a part of the quantity is dedicated to prophylaxis, early detection and smooth sorts of remedy in posttransplant lymphomas. As a end of these kind of new facts, the speculation of immunosurveillance merits to be considerably modified.
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Extra resources for Cancer in Transplantation: Prevention and Treatment: Proceedings of the 27th Conference on Transplantation and Clinical Immunology, 22–24 May 1995
Printed in the Netherlands. 42 G. Karam et al. Table 1. Sites and histological patterns of tumors Site Number Kidney • Bladder (Transitionnal carcinoma) Prostate (Adenocarcinoma) Testis b Unknown Total 19 2 8 3 33 ': Renal cell carcinoma (II), Wilms' tumor (4), oncocytoma (2), adenoma (2) b: Embryonnal carcinoma (2), seminoma (1) Table 2. The different treatments of tumors Kidney Bilateral nephrectomy: 6 Nephrectomy (single kidney): 1 Nephrectomy: 12 Chemoand radiotherapy: 3 Bladder Prostate Type of treatment and Number Trans urethral resection: 1 Trans urethral resection and Mitomycine: 1 Radical prostatectomy: 6 Trans urethral resection: 1 Testis Lymph node dissection and chemotherapy: 2 Lymph node dissection, chemotherapy, radiotherapy: 1 Horrnonotherapy: 1 nephrectomy (or nephrectomy of a solitary kidney) in 8 cases (5 renal cell ca1cinomas,3 Wilms' tumors).
Glioblastoma 1994  multiforme Death 5 months Peritoneal metastases Kidney 5 months Alive 12 months Nephrectomy + Chemotherapy Heart 6 months Death 7 months Widespread metastases Liver Kidney 9 months Death 10 months - Metastases Removal I month-Alive no tumor Alive 25 months No tumor Kidney 17 months Kidney 18 months Removal (2 intrarenal T) Alive 3 months - no tumor Removal (I intrarenal T) Alive 32 months - No tumor Kidney 10 months Kidney 10 months Alive - nephrectomy + irradiation Kidney + Heart Ruiz et al.
3. German multicenter analysis of malignancies following renal replacement therapy in children ANNE-MARGRET WINGEN* Introduction The frequency of malignant diseases in adult patients on dialysis figures at about 4% and rises to about 6% after renal transplantation (RTPL) . Especially the incidence of lymphomas is augmented: 4 times higher on dialysis and 37 times higher after transplantation as compared to age-matched controls. The risk of patients starting renal replacement therapy (RRT) in childhood to develop a de novo malignancy is less well defined, because the observation period under pediatric care is short as compared to their whole lifetime.