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By P. Nicolopoulou-Stamati, M. A. Pitsos (auth.), P. Nicolopoulou-Stamati, L. Hens, C. V. Howard, N. Van Larebeke (eds.)

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R: .. =... 2 20 A. NOVOGRADEC and S. HARRIS ALI In addition, particular attention must be focused on the environmental aetiology of childhood cancer because, generally speaking, 'children are highly vulnerable to environmental toxicants' (Suk, 2002: A284). Citing work by the National Academy of Sciences (NAS, 1993), Suk (2002: A284) points out that this enhanced childhood susceptibility is related to four factors. First, because of metabolic differences, 'children have greater exposures to environmental toxicants than adults'.

2. Growing Cancer Trends In the current world population of 6,157,400,560 (The World Fact Book, 2001) it is estimated that 20 million people have cancer (WHO, 2002: iii). The annual worldwide cancer incidence is estimated to be over 10 million new cases, while 6 million people world-wide succumb to this disease each year. , 1990). 3 per cent of all deaths' (Logan, 1982: 8), while 'today cancer is the second-leading cause of mortality in the developed world and fourth in the developing world - accounting for 12 per cent of all deaths world-wide' (WHO, 2002: 17).

First, the suspected carcinogen doses administered to laboratory animals are in much higher concentrations than those found in the real world; the environment created in a laboratory does not realistically parallel the environment humans live and work in. Consequently, high- to low-dose extrapolations must be made through mathematical models and may introduce uncertainties in the analysis. Second, the need to make animal-to-human comparisons also introduces significant difficulties in interpretation.

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