Download Breast Cancer Metastasis and Drug Resistance: Progress and by Jiemin Ma, Ahmedin Jemal (auth.), Aamir Ahmad (eds.) PDF

By Jiemin Ma, Ahmedin Jemal (auth.), Aamir Ahmad (eds.)

​This quantity comprehensively covers contemporary prrogress in breast melanoma examine. for you to effectively deal with breast melanoma, it truly is central to a) absolutely comprehend the affliction with all its heterogeneity, b) comprehend the criteria that effect the metastasis of breast melanoma to far-off organs making it deadly and c) comprehend the underlying tactics that bring about the phenomenon of drug-resistance making the illness rather incurable. The booklet explores all of those matters, together with the phenomenon of epithelial-mesenchymal-transition, melanoma stem cells in addition to microRNAs in an try and greater comprehend the affliction in connection to its heterogeneity/metastasis/drug-resistance in addition to to suggest novel signaling pathways for healing intervention. The profiling of tumors to molecularly classify breast cancers can be investigated in order that custom-made detailed cures may be built. ​

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Extra info for Breast Cancer Metastasis and Drug Resistance: Progress and Prospects

Sample text

The study results also indicated that longer duration of physical activity provides the most benefit [36]. 10 Anthropometric Factors Anthropometric factors such as body height, weight, and adiposity have been extensively studied in epidemiologic studies of breast cancer [37, 38]. Body fat provides a substrate for the production of estrogen from androgen in adipose tissue [39]. In the Cancer Prevention Study II cohort (n = 495,477 women), Calle et al. found that women with higher values of body mass index had an increased risk of dying from breast cancer and certain other cancers [40].

Age-standardized incidence rates are higher among white women than black women, although black women in the United States have a higher mortality rate than white women. Incidence rates for Asian/Pacific Islander, American Indian/Alaska Native, and Hispanic women in the United States are generally lower than those for white or black women [5, 6] (Fig. 1). The incidence of breast cancer in the United States increased until about 2000 then decreased from 2002 to 2003 [7]. Most of the decrease in that period was among women with estrogen receptor positive cancers [8].

1 Family History of Cancer Having a positive family history of breast cancer is an established risk factor for the disease. Women who have one first degree relative with breast cancer have about a two-fold increased risk of developing breast cancer [64, 65]. Risk increases the younger the relative was at the time of diagnosis and with increasing number of first-degree relatives with breast cancer [3]. About 20 % of breast cancer patients have a family history of the disease in a first degree relative.

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