Download Breast Cancer Epidemiology by Jacques Ferlay, Clarisse Héry, Philippe Autier (auth.), PDF

By Jacques Ferlay, Clarisse Héry, Philippe Autier (auth.), Christopher Li (eds.)

As the commonest melanoma clinically determined between girls world-wide, breast melanoma is a ailment of substantial public well-being value. The variety of proven and hypothesized probability elements for breast melanoma exceeds that of the other melanoma leading to a wealthy, yet advanced and infrequently conflicting literature at the epidemiology of this disorder. Our figuring out of things that give a contribution to breast melanoma possibility, in addition to the biology and molecular foundation for this universal illness, has vastly elevated during the last few many years. This publication offers a finished overview and demanding evaluation of the epidemiology literature on all significant facets of breast melanoma prevalence and mortality, etiology, and results. Chapters are written through across the world well-known leaders within the box and supply a well timed overview of conventional etiologic danger components, in addition to extra lately evaluated exposures. numerous chapters also are dedicated to scientific features of breast melanoma together with screening, analysis and remedy, and survival. for that reason, this is often the main updated and finished ebook on breast melanoma epidemiology available.

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Extra resources for Breast Cancer Epidemiology

Example text

Additionally, while ER– tumors are most likely to exhibit patterns of gene expression associated with myoepithelial lineage, ERþ tumors are strongly associated with luminal cell lineage (Jones et al. 2004; Lacroix et al. 2004). The relevance of ER expression as a major discriminator of breast cancer subtypes has been confirmed by gene expression profiling studies (Perou et al. 2000; Sorlie et al. 2001; van’t Veer et al. 2002; van de Vijver et al. 2002; Sorlie et al. 2003; Farmer et al. 2005; Hu et al.

2003; Hartley et al. 2006), have a basal-like molecular phenotype (Millikan et al. 2008), and overexpress p53 (Breast Cancer Linkage Consortium 1997; Sidoni et al. 2003). 2 Breast Cancer Biology and Clinical Characteristics 23 Premenopausal disease is also more likely to be familial (Claus et al. 1990; Sidoni et al. 2003) and, specifically, is strongly associated with BRCA1 mutations (John et al. 2007). These differences in tumor biology contribute to differences in disease survival: 5-year relative survival rates for women diagnosed prior to age 40 years are approximately 78–84% compared to >90% among women diagnosed at age 60 years or older (Ries et al.

Specifically, tumor stage is determined by the size of the tumor, whether the lymph nodes are involved (and how many lymph nodes are involved), and whether the cancer has spread to other parts of the body. Breast tumors may be classified as stage 0–IV according to the American Joint Committee of Cancer (AJCC) staging system, with increasing stage corresponding to increasing tumor size and spread. , in situ breast cancer) is characterized by an accumulation of malignant cells that have not invaded into surrounding tissue.

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