By A. L. Burlingame, Steven A. Carr
Collage of California, San Francisco. complaints of the 3rd assembly of an unidentified symposium at the purposes of mass spectrometry in all components of biomedical laboratory study. 138 participants.
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Extra info for Biological Mass Spectrometry
This is referred to as post‐acceleration detection and is essential for negative ion operation, because the first dynode of the electron multiplier is usually negative and would repel negative ions. Only FT‐ICR measures ion currents by a completely different method. At a fixed magnetic field, all ions of the same m/z value have the same cyclotron frequency and move together in a coherent ion packet. This cyclotron motion of ions is responsible for the induction of an electric current in coils surrounding the cell, m/z being determined from the cyclotron frequency.
Morris, H. , Bordoli, R. , and Bateman, R. H. (1996). High sensitivity collisionally activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal‐acceleration time‐of‐flight mass spectrometer. Rapid Comun. Mass Spectrom. 10, 889–896. O’Connor, P. , and Costello, C. E. (2002). High pressure matrix‐assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation. J. Am. Soc. Mass Spectrom. 13, 402–407. , and Mann, M. (2003).
For any combination of DC and RF fields, only ions of a selected m/z follow stable orbits. The fundamental difference is that ions in a 3D QIT have virtually no component of linear translation, whereas in a linear quadrupole made up of four parallel rods, ions travel along spiral paths, emerging to be detected or diverted into a further mass analyzer. Figure 13A illustrates a simple linear single stage quadrupole analyzer with a channeltron detector. Here, the four rods are cylindrical, although the theoretical optimum cross‐ section is hyperbolic.