By Morten Karsdal
Biochemistry of Collagens, Laminins, and Elastin: constitution, functionality, and Biomarkers presents a accomplished creation to collagen and structural proteins. style I collagen is likely one of the so much plentiful molecules within the physique, taking part in crucial roles in several tissues, fairly bone and epidermis. A key element of kind I collagen is its post-translational adjustments that are crucial for proper synthesis and structural integrity of collagens, for tissue-specific performance, in addition to for program as biomarkers of other pathologies.
This quantity summarizes present info on key structural proteins (collagens, laminins and elastin), stories how those molecules impact pathologies, and describes chosen differences of proteins that lead to altered signaling houses of the unique extracellular matrix part. extra, it discusses the unconventional idea that increasingly more elements of the ECM harbor cryptic signaling capabilities that could be considered as endocrine features. also, it highlights how this information could be exploited to modulate fibrotic disease.
- Provides a accomplished advent to collagen and structural proteins
- Provides perception into rising analytical applied sciences which can notice biomarkers of extracellular matrix degradation
- Includes a bankruptcy devoted to the biomarkers of structural proteins
- Contains insights into the biochemical interactions and adjustments to structural composition of proteins in illness states
Read or Download Biochemistry of Collagens, Laminins and Elastin. Structure, Function and Biomarkers PDF
Best molecular biology books
Views in Supramolecular Chemistry will relate contemporary advancements and new intriguing techniques in supramolecular chemistry. In supramolecular chemistry, our target is to appreciate the molecular chemistry past the covalent bond—the sequence will be aware of goal-orientated supramolecular chemistry.
The publication is a textbook (with many routines) giving an in-depth account of the sensible use of mathematical modelling within the biomedical sciences. The mathematical point required is mostly no longer excessive and the emphasis is on what's required to resolve the true organic challenge. the subject material is drawn, e.
The booklet assumes that hodologies (neural circuits, connectome) does generate psyche, i. e. cognitive actual phenomena. furthermore, the current textbook additionally silences the entire paintings produced in educational neurobiology outdoor the anglophone culture, attempting to impose this tradition´s narrative over the full international.
- Genomic Perl : from bioinformatics basics to working code
- Vitamin-Binding Proteins: Functional Consequences
- Nitric Oxide Biology and Pathobiology
- Eicosanoid Protocols
- Red Cell Structure and Its Breakdown
Additional resources for Biochemistry of Collagens, Laminins and Elastin. Structure, Function and Biomarkers
Type II collagen peptide stimulates Akt leading to nuclear factor-kappaB activation: its inhibition by hyaluronan. Biomed Res 2014;35:193–9.  Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, et al. Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage. Matrix Biol 2006;25:419–29.  Elsaid KA, Chichester CO. Review: collagen markers in early arthritic diseases. Clin Chim Acta 2006;365:68–77.  Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, et al.
Biomark Insights 2012;7:119–26.  Jenkins RG, Simpson JK, Saini G, Bentley JH, Russell AM, Braybrooke R, et al. Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study. Lancet Respir Med 2015;3:462–72.  Sand JM, Knox AJ, Lange P, Sun S, Kristensen JH, Leeming DJ, et al. Accelerated extracellular matrix turnover during exacerbations of COPD. Respir Res 2015;16:69.  rendt-Nielsen L, Eskehave TN, Egsgaard LL, Petersen KK, Graven-Nielsen T, Hoeck HC, et al.
Elastic and collagenous networks in vascular diseases. Cell Struct Funct 2000;25:69–72.  Smith LB, Hadoke PW, Dyer E, Denvir MA, Brownstein D, Miller E, et al. Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers–Danlos syndrome. Cardiovasc Res 2011;90:182–90.  Lisman T, Raynal N, Groeneveld D, Maddox B, Peachey AR, Huizinga EG, et al. A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides.