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NH2 \ CH2N2 (diazomethane). For alkylating agents such as nitrogen mustards, there is likewise evidence of the formation, at least in vitro, of unstable (cationic) intermediates, as discussed by Warwick 3. Urethane is metabolized to the iV-hydroxy derivative, itself carcinogenic and capable of alkylation; in the liver there may be formation of S-ethyl glutathione, and urinary derivatives include ethyl mercapturate. 64 Ethionine appears to be metabolized to S-adenosylethionine, but it is uncertain whether this intermediate is responsible for the observed ethylation of nucleic acids 2 2* 1 8 7.

V benzfajacridine (1,2-benzacridine). Ring numbering in parentheses refers to the parent compound, acridine. -phenylazoaniline (4-dimethylaminoazobenzene). VII 4-amino-2',3-dimethylphenylazobenzene (a-aminoazotoluene). VIII A^-2-fluorenylacetamide (2-acetylaminofluorene, 2acetamidofluorene). g. g. 1,2 : 3,4-diepoxybutane [I]. g. dibenz[fl-/*]anthracene (the first chemical carcinogen to be discovered — E. L. g. ) [VI], and 4-amino-2',3-dimethylphenylazobenzene (AAT) [VII]. g. iV-2-fluorenylacetamide (AAF) [VIII], 2-naphthylamine, and 4-aminostilbene.

Furth 4 8). Viruses from exogenous sources are clearly not primary causes of all tumours, but it has been suggested that activation of endogenous viruses — which can indeed occur after irradiation (H. S. Kaplan 2 1, R. Latarjet 2 1) — underlies cancer other than 42 Biochemical Approaches to Cancer that produced by deliberately administering viruses. In this connection it is of interest that the production of the anti-virus agent interferon may be suppressed in virus-infected cells exposed to carcinogenic hydrocarbons in vitro (E.

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