Download Advances in Cancer Research, Vol. 13 by George Klein, Sidney Weinhouse, Alexander Haddow (Eds.) PDF

By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)

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Additional resources for Advances in Cancer Research, Vol. 13

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HALL early stages of tumor growth, antigen is released and is carried via the afferent lymphatics to the regional node and a normal immune response is induced so that specifically reactive immunoblasts are discharged into the lymph and ultimately the blood. However, if tumor growth is not halted a t this stage, more and more antigenic material impinges on the draining node. We speculate that the antigen reacts with newly formed immunoblasts in the node and immobilizes them so that, instead of being released into the efferent lymph, they settle down in the medulla of the node and transform into plasma cells.

E x p t l . Med. 119, 377-388. Rudenstam, C. M. (1970). Proc. 4th Conf. Cancer. Immunity Tolerance Oncogenesis. , Perugia, Italy (in press). IMMUNOBLASTS I N RESISTANCE TO CANCER 37 Schild, H. , and Willoughby, D. A. (1967). Brit. M e d . Bull. 23, 4 6 5 1 . Stetson, C. A. (1963). Advan. Irnmunol. 3, 97-130. ,and Gowans, J. L. (1965). J . Ezptl. Med. 122, 347360. Waksman, B. H. (1968). Federation Proc. 27, 45-46. , and Hildeman, W. H. (1968). Science 162, i293-1295. Wilson, D. B. (1967). J . Exptl.

The malignant cells in any given tumor are fairly uniform and may range from stem cells to mature lymphocytes. Holzworth (1960) has described animals with acute lymphoblastic leukemia but these do not appear to be diagnosed frequently in the field. 3 are encountered in less than 15% of cases (Crighton, 1968). Thus, hematological examination is of little value in diagnosis and prognosis. 1. Transmission of Feline Leukemia Evidence that an infectious agent might be involved in the etiology of lymphosarcoma in the cat was provided in 1964 by Jarrett et al.

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